CRISPR editing of mitochondria: Promising new biotech? – Phys.org

Although the CRISPR/Cas9 system has seen widespread application in editing the nuclear genome, using it to edit the mitochondrial genome has been problematic. The main hurdles have been a lack of suitable editing sites in the small mtDNA, and the traditional difficulty of importing the guide RNA into the mitochondrial matrix where nucleoids can be accessed.
Two recently published papers suggest that significant progress is being made on both fronts. The first paper, published in the journal SCIENCE…

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