Health
CRISPER-based system suppresses genes related to AAV antibody production – News-Medical.Net
Gene therapy generally relies on viruses, such as adeno-associated virus (AAV), to deliver genes into a cell. In the case of CRISPR-based gene therapies, molecular scissors can then snip out a defective gene, add in a missing sequence or enact a temporary cha…
Reviewed by Emily Henderson, B.Sc.Sep 4 2020
Gene therapy generally relies on viruses, such as adeno-associated virus (AAV), to deliver genes into a cell. In the case of CRISPR-based gene therapies, molecular scissors can then snip out a defective gene, add in a missing sequence or enact a temporary change in its expression, but the body’s immune response to AAV can thwart the whole endeavor.
To overcome that obstacle, researchers at the University of Pittsburgh School of Medicine created a sy…
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