Health
Clinically relevant mutations in core metabolic genes confer antibiotic resistance – Science Magazine
Antibiotic resistance arising from mutation is common among pathogenic bacteria. However, this process is not well understood, and most of the mutations that have…
Structured Abstract
Abstract
Although metabolism plays an active role in antibiotic lethality, antibiotic resistance is generally associated with drug target modification, enzymatic inactivation, and/or transport rather than metabolic processes. Evolution experiments of Escherichia coli rely on growth-dependent selection, which may provide a limited view of the antibiotic resistance landscape. We sequenced and analyzed E. coli adapted to representative antibiotics at increasingly heightened metabolic…
-
Business23 hours agoThe pros and cons of buying CBA shares in September
-
Noosa News23 hours agoRent changes on way for hundreds of social housing recipients following government review
-
Business18 hours agoWhere will Berkshire Hathaway be in 1 year?
-
Noosa News21 hours agoPolice reject claims about detained protester; SEQ train lines to be disrupted; BlueCare to cut enrolled nurses