Health
Cholesterol metabolite causes immune system to attack T cells instead of breast cancer, study finds – University of Illinois News
Illinois researchers found that a cholesterol metabolite hijacks myeloid immune cells to disarm the T-cell immune response to breast cancer.
CHAMPAIGN, Ill. — In breast cancer tumors, a molecule produced when the body breaks down cholesterol hijacks the myeloid immune cells that normally arm T cells to fight cancer, a new study in mice found. Instead, the hijacked myeloid cells disarm the T cells and even tell them to self-destruct.
By inhibiting the enzymes that make that molecule, researchers slowed the cancer’s progression and boosted the efficacy of immune therapy in the mice.
“Metastatic breast cancer is very difficult to trea…
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