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Chemists build natural anti-cancer compound with lean new process – Science Daily
Creative chemists employ enzymes to build a complex but promising natural anti-cancer agent called cepafungin I in a lean nine steps.
Scripps Research chemists Hans Renata, PhD, and Alexander Adibekian, PhD, have discovered a way to efficiently create a synthetic version of a valuable natural compound called cepafungin I, which has shown promise as an anti-cancer agent.Through this, they were able to understand how the bacterial secretion is able to block a piece of molecular machinery known as a proteasome — a strategy that many existing cancer medications use to destroy tumor cells. They found that cepafungin I bound to not…
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