Health
Building bridges: PARP enzymes bring broken DNA together – Mirage News
Corresponding author Mario Halic, Ph.D., of St. Jude Structural Biology, found that PARP2 can bridge the gap to bring two broken DNA ends together. …
“We expected that PARP would bind to DNA and modify chromatin to recruit other DNA repair factors,” said corresponding author Mario Halic, Ph.D., of St. JudeStructural Biology. “Quite unexpectedly, we found that the PARP enzyme itself is bringing two broken DNA ends together.”
DNA is constantly damaged and repaired. This can be naturally occurring or due to exposure to DNA damaging agents like some chemotherapies used to treat cancer. PARP is a family of enzymes known by scientists to be involv…
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