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Build-up of cellular ‘trash’ in the brain can cause neurodegeneration, death – News-Medical.net

A little mess never killed anyone, right? Wrong. Researchers at Tokyo Medical and Dental University (TMDU) have recently shown that a build-up of cellular “trash”…

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Reviewed by Emily Henderson, B.Sc.Nov 19 2020
A little mess never killed anyone, right? Wrong. Researchers at Tokyo Medical and Dental University (TMDU) have recently shown that a build-up of cellular “trash” in the brain can actually cause neurodegeneration, and even death.
Reporting their findings in Nature Communications, the researchers describe how defects in a cellular waste disposal mechanism, called “alternative autophagy”, can lead to a lethal build-up of iron and protein in brain cells.

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