Breast cancer–secreted factors perturb murine bone growth in regions prone to metastasis – Science Advances

INTRODUCTION
Bone metastasis is a leading cause of morbidity and mortality in patients with advanced breast cancer (1, 2). Nevertheless, therapeutic strategies to prevent bone metastasis are lacking, due, in part, to limited understanding of the mechanisms that enable breast cancer cells to seed and eventually develop secondary tumors in the skeleton. Disseminated tumor cells (DTCs) that have spread from the primary breast tumor to bone can colonize early in tumorigenesis (3). This process is potentially…

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