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Breaking Bad: How Shattered Chromosomes Make Cancer Cells Drug-Resistant – UC San Diego Health

UC San Diego and Ludwig Cancer Research scientists describe how a phenomenon known as “chromothripsis” breaks up chromosomes, which then reassemble in ways that…

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In this scanning electron micrograph of inside the nucleus of a cancer cell, chromosomes are indicated by blue arrows and circular extra-chromosomal DNA are indicated by orange arrows. Image courtesy of Paul Mischel, UC San Diego.
Cancer is one of the world’s greatest health afflictions because, unlike some diseases, it is a moving target, constantly evolving to evade and resist treatment. 
In a paper published in the December 23, 2020 online issue of Nature, researchers at University of California…

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