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BBB pathophysiology–independent delivery of siRNA in traumatic brain injury – Science Advances
Small interfering RNA (siRNA)–based therapeutics can mitigate the long-term sequelae of traumatic brain injury (TBI) but suffer from poor permeability across the…
INTRODUCTION
Referred to as a silent epidemic, traumatic brain injury (TBI) is a leading cause of death and disability among children and young adults, with millions of people sustaining TBI each year in accidents, sports, and military conflicts (13). TBI may lead to potentially long-lasting neurological dysfunctions, memory disturbances, behavioral changes, speech irregularities, and gait abnormalities. It has also been implicated in the development of neurodegenerative disease, particularly chronic…
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