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Angiotensin system polymorphisms in COVID-19 | PGPM – Dove Medical Press

Polymorphisms in the ACE1, ACE2, AGT and AGTR1 genes in patients affected by COVID-19 may provide direction for personalized therapeutic strategies. Learn more.

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Introduction
Over the last two decades, seven coronaviruses responsible for respiratory diseases in humans have been studied and deeply analyzed for their major lung and multi-organ damages (adverse myocardial condition, cardiomyopathy and kidney failures), including the SARS-CoV-2 responsible for COVID-19 pandemic.1–3 The clinical spectrum of SARS-CoV-2 infection varies from the most frequent asymptomatic or mild symptomatic forms to severe progressive pneumonia and death, with specific virulence…

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