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Angiotensin converting enzyme 2 is a novel target of the γ-secretase complex – DocWire News
bioRxiv. 2020 Sep 1:2020.09.01.277954. doi: 10.1101/2020.09.01.277954. Preprint.ABSTRACTAngiotensin converting enzyme 2 (ACE2) is a key regulator of the
bioRxiv. 2020 Sep 1:2020.09.01.277954. doi: 10.1101/2020.09.01.277954. Preprint.
ABSTRACT
Angiotensin converting enzyme 2 (ACE2) is a key regulator of the renin-angiotensin system, but also the functional receptor of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Based on structural similarity with other γ-secretase (γS) targets, we hypothesized that ACE2 may be affected by γS proteolytic activity. We found that after ectodomain shedding, ACE2 is targeted for intramembrane p…
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