Health
An engineered decoy receptor for SARS-CoV-2 broadly binds protein S sequence variants – Science Advances
The spike S of SARS-CoV-2 recognizes ACE2 on the host cell membrane to initiate entry. Soluble decoy receptors, in which the ACE2 ectodomain is engineered to block…
INTRODUCTION
Zoonotic coronaviruses have crossed over from animal reservoirs multiple times in the past two decades, and it is almost certain that wild animals will continue to be a source of devastating outbreaks. Unlike ubiquitous human coronaviruses responsible for common respiratory illnesses, these zoonotic coronaviruses with pandemic potential cause serious and complex diseases, partly due to their tissue tropisms driven by receptor usage. Severe acute respiratory syndrome coronaviruses 1…
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