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Altering balance of fibroblasts could prevent spread of colorectal cancer – Drug Target Review

Researchers found colorectal cancer-associated fibroblasts can be altered with a gremlin 1-neutralising antibody or overexpressing meflin.

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Posted: 1 February 2021 | Victoria Rees (Drug Target Review) | No comments yet
Researchers have found that colorectal cancer-associated fibroblasts can be altered using a gremlin 1-neutralising antibody or by overexpressing meflin.
Researchers have revealed that colorectal cancer tissues contain at least two types of fibroblasts – cancer-promoting fibroblasts and cancer-restraining fibroblasts. The team, from Nagoya University, Japan, found that the balance between the two is largely involved in…

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