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AAV gene therapy often leads to dorsal root ganglion pathology, show studies – News-Medical.Net
A meta-analysis of non-human primate (NHP) studies showed that adeno-associated virus (AAV) gene therapy often caused dorsal root ganglion (DRG) pathology.
Reviewed by Emily Henderson, B.Sc.Sep 3 2020
A meta-analysis of non-human primate (NHP) studies showed that adeno-associated virus (AAV) gene therapy often caused dorsal root ganglion (DRG) pathology. There were no clinical effects.
The study is reported in the peer-reviewed journal Human Gene Therapy.
<spancalibri”,sans-serif”>The dorsal root ganglion is a cluster of neurons in the dorsal root of a spinal nerve. DRG pathology was present in 83% of NHP given AAV through the cerebrospina…
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