Health
A diagnostic host response biosignature for COVID-19 from RNA profiling of nasal swabs and blood – Science Advances
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus disease-19 (COVID-19), has emerged as the cause of a global pandemic. We…
RESULTS
DISCUSSION
Here, we use RNA-seq to characterize the differential host responses to SARS-CoV-2 infection in 286 NP swab and 53 WB samples from 333 individuals. Both NP swabs and WB from patients with COVID-19 show distinct patterns of activation or inhibition relative to other infections (influenza, seasonal coronaviruses, and bacterial sepsis) and to each other. SARS-CoV-2 infection was found to activate IFN-mediated antiviral pathways and paradoxically inhibit multiple additional immune…
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