Science
Autophagy: the beginning of the end – EurekAlert
Autophagy, from the Greek for ‘self-eating’, is an essential process that isolates and recycles cellular components under conditions of stress or when resources are limited. Scientists led by Sascha Martens from the Max Perutz Labs have now reconstructed the …
Autophagosomes first form as cup-shaped membranes in the cell, which then grow to engulf the cellular material designated for destruction. The formation of these membranes is catalyzed by a complex machinery of proteins. “We have a very good knowledge of the factors involved in autophagosomes formation”, explains group leader Sascha Martens, “but how they come together to initiate the formation of these membranes has so far been enigmatic”.
One of the factors is Atg9, a protein whose importance…
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