New class of molecule targets proteins outside cells for degradation – Nature.com

Most drugs act by binding to a specific site in a target protein to block or modulate the proteins function. The activity of many proteins, however, cannot be altered in this way. An emerging class of drug instead brings proteins into proximity with other molecules, which then alter protein function in unconventional ways13. One such approach uses drug molecules called protein degraders, which promote the tagging of proteins with ubiquitin, another small protein. Tagged proteins are then broken …

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