Health
Two-step targeting strategy can increase clinical translation of nanoparticle-based therapies – News-Medical.Net
Therapy-loaded nanoparticles may be directed to the brain by functionalization with ligands targeting BBB-associated proteins.
Reviewed by Emily Henderson, B.Sc.Jul 27 2020
Therapy-loaded nanoparticles may be directed to the brain by functionalization with ligands targeting BBB-associated proteins. However, such targeting strategies have inherent brain-specificity limitations, as the target proteins are also significantly expressed in peripheral organs, thereby limiting the clinical application of such strategies. We have developed a counterintuitive targeting strategy which exploits the high impermeability of the BBB …
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