Health
Diverse noncoding mutations contribute to deregulation of cis-regulatory landscape in pediatric cancers – Science Advances
Interpreting the function of noncoding mutations in cancer genomes remains a major challenge. Here, we developed a computational framework to identify putative causal noncoding mutations of all classes by joint analysis of mutation and gene expression data. W…
INTRODUCTION
Extensive research efforts have identified recurrent mutated genes in multiple types of childhood cancer, including two recent pan-cancer studies that have defined landscapes of coding mutations in common pediatric cancers (1, 2). However, current cancer mutation landscapes are far from complete without systematic analysis of the noncoding portion of the genome. For instance, recurrent leukemia-associated genetic alterations cannot be identified in 10 to 20% of children with acute …
