Science
Odontoblast TRPC5 channels signal cold pain in teeth – Science Advances
Teeth are composed of many tissues, covered by an inflexible and obdurate enamel. Unlike most other tissues, teeth become extremely cold sensitive when inflamed….
INTRODUCTION
Insults to the tooths dentin produces inflammation, most commonly during tooth decay. Dental caries is a chronic disease in which a bacterial biofilm on the tooth surface, in combination with fermentable carbohydrate substrates, causes demineralization and eventually tooth decay. Worldwide, 2.4 billion people have untreated caries in permanent teeth (1). Inflamed teeth are extremely cold sensitive, perceived as a short, sharp intense neuralgic pain (2). On the basis of the functional…
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