Health
Pervasive lesion segregation shapes cancer genome evolution – Nature.com
Mutagenic lesions such as those that give rise to cancer frequently segregate—unrepaired—during cell division, resulting in phasing of multiple alleles across generations of daughter cells and consequent tumour heterogeneity.
1.Martincorena, I. et al. Universal patterns of selection in cancer and somatic tissues. Cell171, 10291041 (2017).
CAS
PubMed
PubMed Central
Google Scholar
2.Turajlic…
Continue Reading