Mutant proteins from SARS-CoV-2 block T cells’ ability to recognize and kill infected cells – EurekAlert

A deep sequencing study of 747 SARS-CoV-2 virus isolates has revealed mutant peptides derived from the virus that cannot effectively bind to critical proteins on the surface of infected cells and, in turn, hamper activation of CD8+ killer T cells that recognize and destroy these infected cells. These peptides, the authors say, represent one way the coronavirus subverts killer T cell responses and stymies immunity in the host. Their results may be of particular importance for SARS-CoV-2 subunit vaccines,…

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