Science
The one-carbon pool controls mitochondrial energy metabolism via complex I and iron-sulfur clusters – Science Advances
Induction of the one-carbon cycle is an early hallmark of mitochondrial dysfunction and cancer metabolism. Vital intermediary steps are localized to mitochondria,…
RESULTS
DISCUSSION
The SLC25 family is almost exclusively responsible for the transport of metabolites, including amino acids, fatty acids, cofactors, inorganic ions, and nucleotides across the inner mitochondrial membrane. The substrate of around one third of SLC25 carriers has not been identified, and selected metabolites are known to be transported by more than one carrier (27). Here, we identified cg4743 as the ortholog of SLC25A26 in Dm and its deletion in both flies and mice established SAMC…
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