Health
Oligodendroglial glycolytic stress triggers inflammasome activation and neuropathology in Alzheimer’s disease – Science Advances
Myelin degeneration and white matter loss resulting from oligodendrocyte (OL) death are early events in Alzheimer’s disease (AD) that lead to cognitive deficits;…
INTRODUCTION
Alzheimers disease (AD) is an age-related neurodegenerative disorder that is characterized by extracellular senile plaques that are composed of deposits of -amyloid (A) and neurofibrillary tangles (NFTs) of hyperphosphorylated tau protein (1). Despite decades of progress in understanding the pathogenesis of AD, the mechanisms that underlie AD-related cellular damage and cognitive deficits remain elusive. Before plaques and tangles become apparent in AD patients, white matter loss and…
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