Health
SARS-CoV-2 hijacks lung cells for its own purposes – The Science Board
The first map of molecular responses of human lung cells to SARS-CoV-2 infection has been developed. It shows that the novel coronavirus causes significant protein…
In the distal lung, SARS-CoV-2 preferentially infects alveolar epithelial type 2 cells (AT2s) which express the angiotensin-converting enzyme 2 (ACE2) receptor and transmembrane protease, serine 2 (TMPRSS2). These cells are progenitors of lung alveoli. Most COVID-19 mortality and morbidity results from alveolar injury, and therefore identifying mechanisms of how SARS-CoV-2 drives lung pathology in these cells is an urgent unmet need.
Alveolar epithelial type 2 cells derived from human-induced pluripotent…
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