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Potency and timing of antiviral therapy as determinants of duration of SARS-CoV-2 shedding and intensity of inflammatory response – Science Advances

To affect the COVID-19 pandemic, lifesaving antiviral therapies must be identified. The number of clinical trials that can be performed is limited. We developed…

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INTRODUCTION
The coronavirus disease 2019 (COVID-19) pandemic is a devastating historical event, which is currently affecting nearly all of mankind. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) incidence is surging in numerous cities and countries across the globe (1), and infection carries a high mortality rate, particularly among the elderly (24). While social distancing has slowed and even eliminated many local epidemics (5), it is not an economically viable long-term strategy….

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