Health
Rapid identification of a human antibody with high prophylactic and therapeutic efficacy in three animal models of SARS-CoV-2 infection – pnas.org
Effective therapies are urgently needed for COVID-19. We rapidly (within a week) identified a fully human monoclonal germline-like antibody (ab1) from phage-displayed…
Abstract
Effective therapies are urgently needed for the SARS-CoV-2/COVID-19 pandemic. We identified panels of fully human monoclonal antibodies (mAbs) from large phage-displayed Fab, scFv, and VH libraries by panning against the receptor binding domain (RBD) of the SARS-CoV-2 spike (S) glycoprotein. A high-affinity Fab was selected from one of the libraries and converted to a full-size antibody, IgG1 ab1, which competed with human ACE2 for binding to RBD. It potently neutralized replication-competent…
-
Noosa News21 hours agoEx-Townsville mayor Troy Thompson lied about army service, degrees, and cancer, says CCC
-
Noosa News21 hours agoSecurity concerns over Chinese-made Yutong fleet dismissed
-
Noosa News23 hours agoQueensland’s domestic violence policing and policies are being shaped by lived experience
-
General14 hours agoEnvironment Bill passes Senate as Greens cut deal with Labor