Health
Researchers discover important second SARS-CoV-2 receptor – The Science Board
Researchers have identified a second receptor that might be important in SARS-CoV-2 infectivity, according to a new report published in Science on October 20. This…
Why is SARS-CoV-2 more pathogenic than previous coronaviruses?
Both SARS-CoV and SARS-CoV-2 uptake is mediated by ACE2 cellular receptors. But unlike the 2003 coronavirus, SARS-CoV-2 has a polybasic furin-type cleavage site at the junction of its S1 and S2 subunits in the spike protein. Similar sites are found on other pathogenic viruses including Ebola, HIV-1, and highly virulent strains of avian flu.
“That SARS-CoV-2 uses the receptor ACE2 to infect our cells was known, but viruses often use multiple…
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