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Coronavirus in human diseases: Mechanisms and advances in clinical treatment – Wiley
Current mechanisms of anti‐CoV therapeutic strategies. The idea to disturb the normal life cycle of the virus provides significant insights into the clinical tr…
4.2.1 Agents based on viral enzymes
All of the major proteases of the virus are attractive druggable targets since they are essential for viral transcription and replication (Table 2). As a key part of replicationtranscription complex, RdRp participates in the production of genomic RNA and subgenomic RNA. Nucleoside analogues targeting RdRp is capable of inhibiting viral RNA synthesis in a great variety of RNA viruses including CoVs.246-250 Favipiravir (T705), a guanine analogue approved in Jap…
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