Why the dose matters: Study shows levels and anti-tumor effectiveness of a common drug vary widely – Science Codex

DALLAS – Sept. 17, 2020 – When used to manage infections, the drug itraconazole is generally given at a single, fixed dose to all patients. But determining the correct dosage of the drug to help treat cancer isn’t that simple, new research by UT Southwestern suggests.
When the team of researchers and clinicians measured how much itraconazole ended up in the bloodstreams and tumors of 13 patients treated for lung cancer, they found a sixfold variation in drug levels in tumor samples. Moreover, …

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