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Drug repurposing screen identifies masitinib as a 3CLpro inhibitor that blocks replication of SARS-CoV-2 in vitro – DocWire News
bioRxiv. 2020 Sep 1:2020.08.31.274639. doi: 10.1101/2020.08.31.274639. Preprint.ABSTRACTThere is an urgent need for anti-viral agents that treat
bioRxiv. 2020 Sep 1:2020.08.31.274639. doi: 10.1101/2020.08.31.274639. Preprint.
ABSTRACT
There is an urgent need for anti-viral agents that treat SARS-CoV-2 infection. The shortest path to clinical use is repurposing of drugs that have an established safety profile in humans. Here, we first screened a library of 1,900 clinically safe drugs for inhibiting replication of OC43, a human beta-coronavirus that causes the common-cold and is a relative of SARS-CoV-2, and identified 108 effective drug…
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