Health
Severely Damaged Human Lungs Can Now Be Successfully Recovered – Columbia University
Columbia Engineering and Vanderbilt researchers demonstrate that human lungs rejected for transplant can be recovered using cross-circulation, to provide much larger number of donor lungs to critically ill patients.
About the Study
The study is titled Xenogeneic cross-circulation for extracorporeal recovery of injured human lungs.
Authors are: Ahmed E. Hozain 1,2, John D. ONeill 1, Meghan R. Pinezich 1, Yuliya Tipograf 2, Rachel Donocoff 3, Katherine M. Cunningham 1, Andrew Tumen 4, Kenmond Fung 5, Rei Ukita 4, Michael Simpson 2, Jonathan A. Reimer 1,2, Edward C. Ruiz 1, Dawn Queen 6, John W. Stokes 4, Nancy L. Cardwell 4, Jennifer Talackine 4, Jinho Kim 7, Hans-Willem Snoeck 8,9, Ya-Wen Chen 8,10, Alexander Romanov 3, Charles C. Marboe 11, Adam D. Griesmer 9, Brandon A. Guenthart 1,12, Matthew Bacchetta 1,4,16,17 and Gordana Vunjak-Novakovic 1,8
1 Department of Biomedical Engineering, Columbia University2 Department of Surgery, Columbia University Medical Center3 Institute of Comparative Medicine, Columbia University Medical Center4 Department of Thoracic Surgery, Vanderbilt University5 Department of Clinical Perfusion, Columbia University Medical Center6 Vagelos College of Physicians and Surgeons, Columbia University Medical Center7 Department of Biomedical Engineering, Stevens Institute of Technology8 Department of Medicine, Columbia University Medical Center9 Department of Microbiology and Immunology, Columbia University Medical Center10 Columbia Center for Human Development, Columbia University Medical Center11 Department of Medicine, University of Southern California12 Department of Stem Cell Biology and Regenerative Medicine, University of Southern California13 Department of Pathology and Cell Biology, Columbia University Medical Center14 Center for Translational Immunology, Columbia University Medical Center15 Department of Cardiothoracic Surgery, Stanford University16 Department of Cardiac Surgery, Vanderbilt University17 Department of Biomedical Engineering, Vanderbilt University
The study was supported by grants from the National Institutes of Health (HL134760, EB27062, HL120046, HL007854), Blavatnik Foundation, and the Mikati Foundation.
The authors declare no competing financial interests.
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