Health
Could heparin-based therapies be a viable treatment for COVID-19? – The Science Board
Researchers have identified a novel approach to treating SARS-CoV-2 infection, spurred by a new understanding of viral attachment involving a heparan sulfate, a common glycoprotein. The results are presented in a September 14 article published in Cell
Some viruses interact with heparan sulfate, a highly negatively charged linear polysaccharide that is attached to a small set of membrane or extracellular matrix proteoglycans. In this format, glycan-binding domains on membrane proteins facilitate initial attachment of virions to glycan receptors, leading to eventual virus engulfment and internalization.
Trimeric spike proteins of SARS-CoV-2 engage human angiotensin-converting enzyme 2 (ACE2) with one or more receptor binding domains (RBD) in t…
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