Health
Study Finds Tar-Like Peptides Block Nucleic Acids, Leading to Motor Neuron Death in Familial ALS – Genetic Engineering & Biotechnology News
Scientists are now working to create animal models that recreate the toxic mechanism, as a platform for testing potential ALS therapies.
Research by scientists at the Spanish National Cancer Research Centre (CNIO) has uncovered a mechanism that may explain what causes neuronal cell death in cases of amyotrophic lateral sclerosis (ALS) that are associated with mutations in a gene known as C9ORF72. The findings suggest that the C9ORF72 gene mutations are toxic because they induce the cell to produce small proteins or peptides that are very rich in arginine, an amino acid that, due to its positive charge and chemical nature, binds very…
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