Health
Hepatitis B Virus Uses Host’s DNA Repair Proteins to Close Circle of Infection – Genetic Engineering & Biotechnology News
Hepatitis B virus has been found to establish chronic infection by using host DNA repair proteins to close gaps in its viral genome.
To establish chronic disease, the hepatitis B virus (HBV) must have its genome of relaxed circular DNA (rcDNA) turned into covalently closed circular DNA (cccDNA). Exactly how rcDNA becomes cccDNA has been unclear, but new details about the transformation have been uncovered by Princeton University researchers. According to the Princeton team, the rcDNA genome, which contains four lesions, undergoes repair by five host proteins.
The new findings appeared March 11 in Nature Communications, in an…
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